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Gut microbiome
Imbalances in gut microorganisms may disrupt normal immune regulation.
Adults 65+ with Medicare
Your Pain Deserves Answers.
See if biological factors may be behind your chronic pain — with the Pain Signal Test.
May be available at no cost to eligible adults 65+ with Medicare Part B or Medicare Advantage, subject to applicable coverage requirements.
Applications are processed through The Pain Signal Test™ at www.thepaintest.com.
See if you qualify
Secure formForm not displaying? Open it directly, or call 1-800-994-7246.
No-cost testing is subject to eligibility and applicable Medicare or insurance coverage requirements. Completing the form does not guarantee testing or trial enrollment.
Understanding chronic pain
It isn’t “all in your head.”
Research suggests pain lasting three months or longer may involve measurable changes in the immune system, gut, and brain — connected systems that influence one another.
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Immune dysregulation
Altered immune responses may allow inflammation to persist.
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Chronic inflammation
Inflammatory signals can continue long after normal healing.
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Gut–brain axis
Gut–brain signaling may amplify pain sensitivity.
What contributes to chronic pain?
Chronic pain often has more than one cause. The Foundation’s estimates of major contributors:
Trauma / Accidents
30%Aging
20%Immune system factors
45%
Our primary program
The Pain Signal Test
A simple blood test designed to look for immune markers and inflammatory signals associated with chronic pain — helping you and your doctor explore whether biological factors may be involved.
A simple blood draw
No complex procedure or preparation.
Objective biological signals
Measures immune and inflammatory markers associated with chronic pain.
No cost for eligible patients
For adults 65+ with Medicare Part B or Medicare Advantage, subject to eligibility and coverage requirements.
After testing · Optional research study
The REVYYV® Trial
Patients whose Pain Signal Test results indicate immune-related factors may be invited to learn about the REVYYV® Trial, a no-cost research study of a supplement developed with a university College of Pharmacy. Participation is voluntary and subject to study eligibility; individual results are not guaranteed.
Symptom areas being studied
- Chronic pain
- Fatigue
- Poor sleep
- Brain fog
- Irritable bowel symptoms
Why trust us
About the Pain Research Foundation™
Dedicated to advancing the science of chronic pain and helping patients access objective testing and research opportunities.
Clinical research
We support research into the biological factors behind chronic pain, including the immune system and gut–brain pathways.
Laboratory testing
Pain Signal Test samples are processed by a clinical laboratory. Ask our team for laboratory details.
Your privacy
Your form answers go only to our secure form provider. We never share your health information with advertisers.
You are not alone
Talk with a real person.
Questions about the test or qualification? Our team can help you with your next step.
Or email info@painfound.com